Intelligent condition monitoring with CNN and signal enhancement for undersampled signals.

High-frequency signals like vibration and acoustic emission are crucial for condition monitoring, but their high sampling rates challenge data acquisition, especially for online monitoring. Our research developed a novel method for condition identification in undersampled signals using a modified convolutional neural network integrated with a signal enhancement approach. A frequency-domain filtering is applied to suppress similar sidebands and obtain more discriminative features of different conditions, followed by an interpolation-based upsampling in the time domain to restore the signal length and strengthen the low-frequency harmonic information. Enhanced signals are converted into two-dimensional grayscale images for neural network analysis. Tested on bearing datasets and real-world data from regenerative thermal oxidizer lift valve leakage, our method effectively extracts features from low-frequency signals, achieving over 95% fault identification accuracy.

Revealing Size-Dependency of Ionic Liquid to Assist Perovskite Film Formation Mechanism for Efficient and Durable Perovskite Solar Cells.

Ionic liquids (ILs) are extensively utilized for the manipulation of crystallization kinetics of perovskite, morphology optimization, and defect passivation for the fabrication of highly efficient and stable devices. However, comparing ILs with different chemical structures and selecting the appropriate ILs from the many types available to enhance perovskite device performance remains a challenge. In this study, a range of ILs containing different sizes of anions are introduced as additives for assisting in film formation in perovskite photovoltaics. Specifically, ILs with various sizes significantly affects the strength of chemical interaction between ILs and perovskite composition, inducing varying degrees of conversion of lead iodide to perovskite as well as the formation of perovskite films with markedly disparate grain sizes and morphology. Theoretical calculations in conjunction with experimental measurements revealed that small-sized anion can more effectively reduce defect density by filling halide vacancies within perovskite bulk materials, resulting in suppression of charge-carrier recombination, an extended photoluminescence lifetime, and significantly improved device performance. Boosted by ILs with appropriate size, the champion power conversion efficiency of 24.09% for the ILs-treated device is obtained, and the unencapsulated devices retain 89.3% of its original efficiency under ambient conditions for 2000 h.

Tailoring Ionic Liquid Chemical Structure for Enhanced Interfacial Engineering in Two-Step Perovskite Photovoltaics.

Ionic liquids (ILs) have emerged as versatile tools for interfacial engineering in perovskite photovoltaics. Their multifaceted application targets defect mitigation at SnO2 -perovskite interfaces, finely tuning energy level alignment, and enhancing charge transport, meanwhile suppressing non-radiative recombination. However, the diverse chemical structures of ILs present challenges in selecting suitable candidates for effective interfacial modification. This study adopted a systematic approach, manipulating IL chemical structures. Three ILs with distinct anions are introduced to modify perovskite/SnO2 interfaces to elevate the photovoltaic capabilities of perovskite devices. Specifically, ILs with different anions exhibited varied chemical interactions, leading to notable passivation effects, as confirmed by Density Functional Theory (DFT) calculation. A detailed analysis is also conducted on the relationship between the ILs' structure and regulation of energy level arrangement, work function, perovskite crystallization, interface stress, charge transfer, and device performance. By optimizing IL chemical structures and exploiting their multifunctional interface modification properties, the champion device achieved a PCE of 24.52% with attentional long-term stability. The study establishes a holistic link between IL structures and device performance, thereby promoting wider application of ILs in perovskite-based technologies.

Dimethylammonium Cation-Induced 1D/3D Heterostructure for Efficient and Stable Perovskite Solar Cells.

Mixed-dimensional perovskite engineering has been demonstrated as a simple and useful approach to achieving highly efficient and more-durable perovskite solar cells (PSCs), which have attracted increasing research interests worldwide. In this work, 1D/3D mixed-dimensional perovskite has been successfully obtained by introducing DMAI via a two-step deposition method. The additive DMA+ can facilitate the crystalline growth and form 1D DMAPbI3 at grain boundaries of 3D perovskite, leading to improved morphology, longer charge carrier lifetime, and remarkably reduced bulk trap density for perovskite films. Meanwhile, the presence of low-dimension perovskite is able to prevent the intrusion of moisture, resulting in enhanced long-term stability. As a result, the PSCs incorporated with 1D DMAPbI3 exhibited a first-class power conversion efficiency (PCE) of 21.43% and maintained 85% of their initial efficiency after storage under ambient conditions with ~45% RH for 1000 h.

A successful extracorporeal cardiopulmonary resuscitation for severe status asthmaticus with an ultra-long cardiac arrest.

The mortality of severe asthma with cardiac arrest is still close to 100% even if it is treated with conventional cardiopulmonary resuscitation (CCPR). Extracorporeal cardiopulmonary resuscitation (ECPR) has been widely accepted as an alternative method when CCPR is futile. However, the maximum "low-flow" duration has not been well defined. Here, we reported a 55-year-old male with severe asthma with cardiac arrest, who was successfully treated with ECPR after 100 min of ultra-long CCPR. He was withdrawn from extracorporeal membrane oxygenator and ventilator at 72 h and 14 days after admission respectively and was discharged without permanent neurologic sequelae. This case illustrates the critical role of ECPR as a last resort in near-fatal asthma. For such patients with bystander, starting ECPR after >60 min of CCPR can still obtain satisfactory prognoses.

A Fault Diagnosis Scheme Using Hurst Exponent for Metal Particle Faults in GIL/GIS.

A diagnosis scheme using the Hurst exponent for metal particle faults in GIL/GIS is proposed to improve the accuracy of classification and identification. First, the diagnosis source signal is the vibration signal generated by the collision of metal particles in the electric field. Then, the signal is processed via variational mode decomposition (VMD) based on particle swarm optimization with adaptive parameter adjustment (APA-PSO). In the end, fault types are classified and identified by an SVM model, whose feature vector is composed of the Hurst exponents of each intrinsic mode function (IMF-H). Extensive experimental data verify the effect of this new scheme. The results exhibit that the classification performance of SVM is significantly improved by the new feature vector. Furthermore, the VMD based on APA-PSO with adaptive parameter adjustment can effectively enhance the decomposition quality.

A simple strategy for the detection of Pb(II) and Cu(II) by an electrochemical sensor based on Zn/Ni-ZIF-8/XC-72/Nafion hybrid materials.

In this study, a novel electrochemical sensor for simultaneous detection of Pb(II) and Cu(II) was constructed by using Zn/Ni-ZIF-8/XC-72/Nafion hybrid material as electrode surface modifier. XRD, FT-IR, XPS and SEM were used to study the crystal structure, functional groups, element types and morphologies of the prepared materials. The electrochemical performance of the Zn/Ni-ZIF-8/XC-72/Nafion/GCE sensor were investigated by CV, EIS and DPV. In addition, the effects of various conditions including pH, the type of buffer and the ratio of Zn/Ni-ZIF-8 to XC-72 were also explored for the determination of Pb(II) and Cu(II). Under the optimum conditions, the constructed sensor exhibited outstanding linear response of Pb(II) (0.794-39.6 ppm) and Cu(II) (0.397-19.9 ppm) with detection limits of 0.0150 and 0.0096 ppm, respectively. Finally, the fabricated sensor was further used to detect Pb(II) and Cu(II) in real samples, and the satisfactory recovery was obtained.

Diagnosis and etiological identification in severe constrictive pericarditis in a 14-year-old girl: a case report.

Constrictive pericarditis in children is exceedingly rare, and may cause very problematic confusion of diagnosis and etiology identification. In this case, we examined a 14-year-old female patient who had developed signs of significant anasarca which was eventually turned out to be constrictive pericarditis. Affected by the experience of examiners, the patient was not diagnosed or even suspected with constrictive pericarditis when she was initially examined by echocardiography in the hospital where she visited before. Reexamination of echocardiography, cardiac catheterization and non-invasive image techniques were performed to establish the diagnosis finally. Open pericardectomy was ultimately performed and normal hemodynamic parameters and cardiac function were obtained postoperatively. In the determination of etiology, we inferred that chronic infection induced by local virus infection in the pericardium led to constrictive pericarditis. Parvovirus B19 (PVB19) and/or human herpes virus 6 (HHV-6) were the two most likely viruses involved based on published literature reviews. Importantly, we learned that serological antibody testing may be false-negative and polymerase chain reaction (PCR) or metagenomic next-generation sequencing for pericardial viral nucleic acid testing may be the gold standard for confirmation. Unfortunately, fresh pericardial tissue samples were not taken before paraformaldehyde fixation in our case, which made it impossible for us to detect suspicious viruses. We do hope that the lessons learned from this case will be helpful and instructive for the etiological diagnosis of similar patients in the future.

Extracorporeal membrane oxygenation for near fatal asthma with sudden cardiac arrest.

INTRODUCTION: Near fatal asthma is a life-threatening disorder that requires mechanical ventilation. Near fatal asthma and COPD with sudden cardiac arrest can worsen the outcomes. Previous studies demonstrated that ECMO is a live-saving measure for near fatal asthma that does not respond to traditional treatment. CASE STUDY: A patient with near fatal asthma (NFA) and COPD presented with high airway resistance, life-threatening acidemia and severe hypoxemia that failed to respond to conventional therapy. His hospital course was complicated by sudden cardiac arrest when preparing to initiate V-V mode extracorporeal membrane oxygenation (ECMO). The mode immediately changed from V-V to V-A, then to V-AV and finally to V-V mode in order to improve cardiac function and promote recovery of lung function. RESULTS: On the sixth day, ECMO was removed and on the ninth day, he was extubated and transferred to the ward. Finally, the patient was discharged home on the nineteenth day after admission to be followed up in the pulmonary clinic. CONCLUSIONS: The early application of ECMO and mode changing plausibly resulted in dramatic improvement in gas exchange and restoration of cardiac function. This case illustrates the critical role of ECMO mode changing as salvage therapy in NFA and COPD with sudden cardiac arrest.

Downregulation of circFASTKD1 ameliorates myocardial infarction by promoting angiogenesis.

Circular RNAs (circRNAs), a novel class of endogenous long non-coding RNAs, have attracted considerable attention due to their closed continuous loop structure and potential clinical value. In this study, we investigated the function of circFASTKD1 in vascular endothelial cells. CircFASTKD1 bound directly to miR-106a and relieved its inhibition of Large Tumor Suppressor Kinases 1 and 2, thereby suppressing the Yes-Associated Protein signaling pathway. Under both normal and hypoxic conditions, the ectopic expression of circFASTKD1 reduced the viability, migration, mobility and tube formation of vascular endothelial cells, whereas the downregulation of circFASTKD1 induced angiogenesis by promoting these processes. Moreover, downregulation of circFASTKD1 in mice improved cardiac function and repair after myocardial infarction. These findings indicate that circFASTKD1 is a potent inhibitor of angiogenesis after myocardial infarction and that silencing circFASTKD1 exerts therapeutic effects during hypoxia by stimulating angiogenesis in vitro and in vivo.

Electrochemical determination of lead(II) and copper(II) by using phytic acid and polypyrrole functionalized metal-organic frameworks.

A glassy carbon electrode (GCE) was modified with a composite prepared from phytic acid, polypyrrole and a ZIF type metal-organic framework (PA/PPy)/ZIF-8@ZIF-67). The nanocomposite was prepared by in-situ chemical polymerization in the presence of ferric chloride and subsequently functionalized with PA to form PA/PPy/ZIF-8@ZIF-67. The materials were characterized by XRD, FT-IR, BET, XPS, SEM and TEM. The modified GCE was applied to individual and simultaneous detection of Pb(II) and Cu(II), with peak voltages of -0.6 and - 0.1 V, respectively (vs. SCE). The amount of PPy, the ZIF-8@ZIF-67 concentration, polymerization potential, polymerization time and pH value were optimized. Under optimized conditions, the calibration plots have two linear ranges. These are from 0.02 to 200 µM and from 200 to 600 µM for Pb(II), and from 0.2 to 200 µM and 200 to 600 µM for Cu(II). The detection limits are 2.9 nM and 14.8 nM, respectively. Simultaneous detection of Pb(II) and Cu(II) is also demonstrated. The good performance of the electrode is attributed to the large surface area of ZIF-8@ZIF-67, the good electrical conductivity of PPy, and the metal complexation power of PA. The modified GCE was successfully applied to the determination of Pb(II) and Cu(II) in real samples and gave satisfactory recoveries. Graphical abstractSchematic presentation of the construction process of PA/PPy/ZIF-8@ZIF-67/GCE sensor, and the mechanism of Pb(II) and Cu(II) at the prepared sensor.

Metal-organic framework-based molecularly imprinted polymer as a high sensitive and selective hybrid for the determination of dopamine in injections and human serum samples.

A highly sensitive and selective molecular imprinting polymer (MIP) sensor was fabricated based on polypyrrole (PPy)/ZIF-67/Nafion hybrid modified glassy carbon electrode (GCE) for the determination of dopamine (DA). The ZIF-67 material was facilely prepared by using hydrothermal synthesis method; subsequently, the PPy/ZIF-67/Nafion hybrid was obtained through a one-pot synthesis method. The physical properties of the materials and the modified sensors were investigated by using X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Nitrogen adsorption-desorption isothermal (BET), X-ray photoelectron spectroscopy (XPS), Scanning electron microscope (SEM) and Atomic force microspectroscopy (AFM) apparatus. Cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscope (EIS) were used to evaluate the electrochemical performance of the sensors. The influence factors controlling the performance of the MIP sensor were studied and included scan rate, pH value and scan cycles. Under optimal conditions, DPV peak was linearly related to DA concentration over two concentration intervals (0.08-100 µM and 100-500 µM). The detection limit of PPy/ZIF-67-MIPs/Nafion/GCE sensor for DA was 0.0308 µM (S/N = 3) and sensitivity was equal to 1.656 µA µM cm-2. Furthermore, good reproducibility, long-term stability and favorable selectivity were obtained in the experiment. Moreover, the fabricated MIP sensor was successfully applied in the determination of DA concentrations in injection and human serum samples with satisfactory recoveries.

External Validation of Survival-Predicting Models for Acute Myocardial Infarction with Extracorporeal Cardiopulmonary Resuscitation in a Chinese Single-Center Cohort.

BACKGROUND This study was designed as an external evaluation of potentially relevant models for acute myocardial infarction (AMI) with extracorporeal cardiopulmonary resuscitation (E-CPR). MATERIAL AND METHODS Twenty AMI adults that met criteria were retrospectively analyzed from January 2009 to January 2015. Six possible models - ENCOURAGE, SAVE, ECPR, GRACE, SHOCK, and a simplified risk chart - were identified by literature review and model scores calculated based on original data. Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment, commonly used in intensive care units, served as controls. A receiver operating characteristic curve was used to compare the models' discriminative power for predicting survival to discharge. RESULTS The ECPR model showed the best discriminative performance, with an area under the curve (AUC) of 0.893 (95% confidence interval [CI], 0.733-1.530, p=0.006); the cutoff was 12.5 points, with 66.7% sensitivity and 100% specificity. The "clinical" SHOCK model (including infarct site) showed weaker but still good discriminative power, with an AUC of 0.804 (95% CI, 0.580-1.027, p=0.035); the cutoff was 45.5 points, with 83.3% sensitivity and 71.4% specificity. The remaining models did not show significant discriminative power for predicting survival to discharge. Risk stratifications indicated that a statistically significant difference was observed in the distribution of patients into the ECPR group with different prognoses when stratified by its cutoff (p=0.003), while a trend of significant difference was shown when applied to the SHOCK model (p=0.05). CONCLUSIONS The ECPR and SHOCK models possess important abilities to predict intrahospital outcomes of AMI patients treated with E-CPR.

[Massive pulmonary embolism similar to acute myocardial infarction rescued by ECMO: a case report].

Acute myocardial infarction (AMI) and acute massive pulmonary embolism can be characterized by no pulse electrical activity. Patients of cardiac arrest (CA) with no pulse electrical activity have a high mortality rate before the cause was corrected. Extracorporeal membrane oxygenation (ECMO), as a kind of artificial heart-lung support organ, provides treatment for CA patients. A case of massive pulmonary embolism similar to AMI was treated in the Third Central Hospital of Tianjin, who received interventional thrombolysis assisted by ECMO. Through the review of the overall development of the case, we aim to broaden the diagnosis and treatment of CA patients with no pulse electrical activity, and to improve the understanding of the complications secondary to ECMO.

Extracorporeal Membrane Oxygenation Outcomes in Acute Respiratory Distress Treatment: Case Study in a Chinese Referral Center.

BACKGROUND No definitive conclusions have been drawn from the available data about the utilization of extracorporeal membrane oxygenation (ECMO) to treat severe acute respiratory distress syndrome (ARDS). The aim of this study was to review our center's experience with ECMO and determine predictors of outcome from our Chinese center. MATERIAL AND METHODS We retrospectively analyzed a total of 23 consecutive candidates who fulfilled the study entry criteria between January 2009 and December 2015. Detailed clinical data, ECMO flow, and respiratory parameters before and after the introduction of ECMO were compared among in-hospital survivors and nonsurvivors; factors associated with mortality were investigated. RESULTS Hemodynamics and oxygenation parameters were significantly improved after ECMO initiation. Thirteen patients survived to hospital discharge. Univariate correlation analysis demonstrated that APACHE II score (r=-0.463, p=0.03), acute kidney injury (r=-0.574, p=0.005), membrane oxygenator replacement (r=-0.516, p=0.014) and total length of hospital stay (r=0.526, p=0.012) were significantly correlated with survival to hospital discharge, and that the evolution of the levels of urea nitrogen, platelet, and fibrinogen may help to determine patient prognosis. Sixteen patients referred for ECMO from an outside hospital were successfully transported to our institution by ambulance, including seven transported under ECMO support. The survival rate of the ECMO-transport group was comparable to the conventional transport or the non-transport group (both p=1.000). CONCLUSIONS ECMO is an effective alternative option for severe ARDS. APACHE II score on admission, onset of acute kidney injury, and membrane oxygenator replacement, and the evolution of levels of urea nitrogen, platelet, and fibrinogen during hospitalization may help to determine the in-hospital patient prognosis. By establishing a well-trained mobile ECMO team, a long-distance, inter-hospital transport can be administered safely.

Performance of Multiple Risk Assessment Tools to Predict Mortality for Adult Respiratory Distress Syndrome with Extracorporeal Membrane Oxygenation Therapy: An External Validation Study Based on Chinese Single-center Data.

BACKGROUND: There has been no external validation of survival prediction models for severe adult respiratory distress syndrome (ARDS) with extracorporeal membrane oxygenation (ECMO) therapy in China. The aim of study was to compare the performance of multiple models recently developed for patients with ARDS undergoing ECMO based on Chinese single-center data. METHODS: A retrospective case study was performed, including twenty-three severe ARDS patients who received ECMO from January 2009 to July 2015. The PRESERVE (Predicting death for severe ARDS on VV-ECMO), ECMOnet, Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) score, a center-specific model developed for inter-hospital transfers receiving ECMO, and the classical risk-prediction scores of Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (SOFA) were calculated. In-hospital and six-month mortality were regarded as the endpoints and model performance was evaluated by comparing the area under the receiver operating characteristic curve (AUC). RESULTS: The RESP and APACHE II scores showed excellent discriminate performance in predicting survival with AUC of 0.835 (95% confidence interval [CI], 0.659-1.010, P = 0.007) and 0.762 (95% CI, 0.558-0.965, P = 0.035), respectively. The optimal cutoff values were risk class 3.5 for RESP and 35.5 for APACHE II score, and both showed 70.0% sensitivity and 84.6% specificity. The excellent performance of these models was also evident for the pneumonia etiological subgroup, for which the SOFA score was also shown to be predictive, with an AUC of 0.790 (95% CI, 0.571-1.009, P = 0.038). However, the ECMOnet and the score developed for externally retrieved ECMO patients failed to demonstrate significant discriminate power for the overall cohort. The PRESERVE model was unable to be evaluated fully since only one patient died six months postdischarge. CONCLUSIONS: The RESP, APCHAE II, and SOFA scorings systems show good predictive value for intra-hospital survival of ARDS patients treated with ECMO in our single-center evaluation. Future validation should include a larger study with either more patients' data at single-center or by integration of domestic multi-center data. Development of a scoring system with national characteristics might be warranted.

Insight into Metalized Interfaces in Nano Devices by Surface Analytical Techniques.

Connections between metals and heterogeneous solid state materials form buried interfaces. These ubiquitous structures play an essential role in determining the performances of many nano- and microdevices. However, the information about the chemistry, structure, and properties of these real interfaces is intrinsically difficult to extract by traditional techniques. Therefore, approaches to efficiently discovering metalized interfaces are in high demand. Here, we demonstrate the transformation of nanoscale metal/oxide interface problems into surface problems through a novel metal-hydrogenation detaching method. We applied this technique to study the thickness dependence in Pb(Zr,Ti)O3 (PZT) ferroelectric thin films, a long-standing interface problem in a model metal/insulator device, and this allowed comprehensive surface analytical techniques to be adapted. A nonstoichiometric interfacial layer of 4.1 nm thick with low mass density, low permittivity, and weak ferroelectricity was quantified at the Pt/PZT interface and attributed to the preferential diffusions among the compositional elements. Targeted interface engineering by Pb rebalance led to a substantial recovery of ferroelectric properties. Our results therefore pave the way to a better understanding of metallized interface in ferroelectric and dielectric nanodevices. We hope that more useful information about metalized interfaces of other solid materials could, analogously, be accessed by surface analytical techniques.

[Comparison of extracorporeal membrane oxygenation and mechanical ventilation for inter-hospital transport of severe acute respiratory distress syndrome patients].

OBJECTIVE: To compare inter-hospital transport and clinical outcome in severe acute respiratory distress syndrome (ARDS)patients whom were transported either on extracorporeal membrane oxygenation (ECMO) or on conventional ventilation, and to investigate the optimal means of inter-hospital transport. METHODS: Eleven patients with severe ARDS who were invalid under conventional ventilation and were transported from other hospitals to Tianjin Third Central Hospital from November 2009 to January 2014 were analyzed. Five patients were transported on ECMO (observation group) and 6 on conventional ventilation (control group). The clinical characteristics, outcomes, transportation, vital signs before and after transportation, respiratory parameters, and Murray score between two groups were compared. RESULTS: Patients in observation group were significantly older than those in control group [years: 73 (46,77) vs. 34 (23,46), Z=-2.293, P=0.022]. There was no significant difference between observation group and control group in acute pathologic and chronic health evaluation II (APACHEII) score, Murray score, oxygenation index (PaO2/FiO2) before transportation, transit time, and transit distance [APACHEII score: 36 (33,39) vs. 27(23,35), Z=-1.830, P=0.067; Murray score: 3.5 ± 0.3 vs. 3.4 ± 0.2, t = 0.667, P = 0.524; PaO2/FiO2(mmHg,1 mmHg=0.133 kPa): 61 ± 14 vs. 63 ± 14, t = -0.249, P=0.809;transit time(minutes): 24 (18, 74) vs. 79 (41, 86), Z=-1.654, P = 0.098; transit distance(km): 12.9 (8.3, 71.8) vs. 72.4 (39.5, 86.8), Z = -1.651, P = 0.099]. There was no significant difference between two groups in vital signs and respiratory parameters before transportation. When arrived in ECMO centre, heart rate, respiratory rate, fractional inspired oxygen, inspiratory pressure and Murray score in observation group were significantly lower than those in control group [heart rate(beat/min):102 ± 16 vs. 136 ± 8, t = -4.374, P = 0.002; respiratory rate(beat/min): 23 ± 3 vs. 37 ± 2, t = -7.967, P = 0.000;fractional inspired oxygen: 0.40 ± 0.05 vs. 0.96 ± 0.09, t=-12.152, P=0.000;inspiratory pressure (cmH2O, 1 cmH2O = 0.098 kPa): 21 ± 1 vs. 34 ± 4, t=-6.887, P = 0.000; Murray score: 2.7 ± 0.2 vs. 3.8 ± 0.2, t = -8.573, P = 0.000], but PaO2/FiO2was higher than that of control group(mmHg: 278 ± 65 vs. 41 ± 5 , t = 8.075, P = 0.001). Four patients were survived in observation group, and one died from the shortage of oxygen induced lung injury deterioration during transportation. Three patients died in control group, which was directly associated with lung injury deterioration. CONCLUSIONS: For patients with severe ARDS who need the support of ECMO, ECMO-assisted transfer is safer than conventional ventilation, but transfer should be implemented by experienced team.

Preparation of sustained-release composite coating formed by dexamethasone and oxidated sodium alginate.

Inflammatory reaction and thrombosis are the unsolved main problems of non-coated biomaterials applied in cardiac surgery. In the present study, a series of sustained composite coating was prepared and characterized, such as in the chemical modification of polyvinyl chloride (PVC) for applications in cardiac surgery and the assessment of the biological property of modified PVC. The composite coatings were mainly formed by dexamethasone (DXM) and oxidated sodium alginate (OSA) through ionic and covalent bond methods. The biocompatibility and hemocompatibility of the coating surface were evaluated. Scanning electron microscopy analysis of the surface morphologies of the thrombus and platelets revealed that DXM-OSA coating improved the antithrombogenicity and biocompatibility of PVC circuits, which were essential for cardiac pulmonary bypass surgery. Evaluation of in vitro release revealed that the DXM on group PPC was gradually released in 8 h. Thus, DXM that covalently combined on the PVC surface showed sustained release. By contrast, DXM on groups PPI and PPD was quickly or shortly released, suggesting that groups PPI and PPD did not have sustained-release property. Overall, results indicated that the DXM-OSA composite coating may be a promising coating for the sustained delivery of DXM.